Does bonding of a female to a sexual partner chemically differ—higher or lower/likelihood—when the brain is in a state of depression?

During what circumstances does female bonding to a partner increase or decrease/is more or less likely specifically taking sex in isolation of all other factors?

How does someone figure out how to balance matters of the physical world with the pursuit of knowledge and the theoretical world? I think it is actually something that can never be done perfectly at a given moment, but over an infinite period of time, is possible. And the balancing of which is done through signals in the brain itself. Because the brain strives for that state of balance and peace. If those signals are listened to, it is possible. Simply.